Prolonged inhibition of meal‐stimulated acid secretion and gastrin release following single subcutaneous administration of octreotide (SMS 201–995) in man

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Abstract
SUMMARY: Single subcutaneous doses of the somatostatin analogue, SMS 201–995, were evaluated for the degree and duration of effects on acid secretion, serum gastrin levels, and gastric emptying in eight human male subjects (mean age 44 years) over an 8‐h period. All the subjects received subcutaneous 50‐μg and 100‐μg doses of SMS 201–995 and placebo on three separate days in a double‐blind random order. Drug or placebo was administered at time 0 followed by peptone meals at time 0, 2, 4, and 6‐h. Peptone meals were evacuated at time 1, 3, 5 and 7‐h to create ‘basal’conditions between alternate hours. Gastric acid secretion was determined hourly beginning at time −1. Both the 50‐μg and 100‐μg doses of SMS 201–995 significantly inhibited ‘basal’and peptone meal‐stimulated gastric acid secretion throughout the 8‐h measurement period. The minimum effective plasma concentration of SMS 201–995 for inhibition of peptone meal‐stimulated gastric acid secretion was approximately 1000 pg/ml. Peptone meal‐stimulated plasma gastrin