COMPARISON OF ONSET OF ACTION AND THERAPEUTIC EFFICACY OF AMOXAPINE AND AMITRIPTYLINE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 39  (7) , 633-637
Abstract
A total of 61 moderately to severely depressed outpatients were treated for 4 wk with either amoxapine (a dibenzoxapine tricyclic) or amitriptyline. This double blind study showed that amoxepine was as effective as amitriptyline and had a earlier onset of action. Maximum doses used were 300 mg of amoxapine and 150 mg of amitriptyline. Side effects were similar for the 2 drugs, except for impotence or loss of libido in 8 male amoxapine, as against 3 amitriptyline patients. Laboratory, ECG, and vital signs findings showed no pathological trends.

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