Antibody Responses in Nasal Secretions and Serum of Elderly Persons Following Local or Parenteral Administration of Inactivated Influenza Virus Vaccine
Open Access
- 1 March 1969
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 102 (3) , 555-562
- https://doi.org/10.4049/jimmunol.102.3.555
Abstract
Summary: Nasal secretion and serum neutralizing antibody responses of 22 elderly persons to vaccination with a bivalent inactivated influenza virus vaccine by local or parenteral routes were compared. Each 1.0 ml of vaccine contained 300 chicken cell agglutination (CCA) units each of A2/Taiwan/1/64 and A2/Japan/170/62, and 600 CCA units of B/Mass/3/66 influenza virus antigens. The titers and duration of IgA antibody in nasal secretions were higher and appeared to persist longer following repeated nasopharyngeal vaccination than after a single subcutaneous immunization. The frequency and duration of serum antibody responses induced by local administration of vaccine were not significantly different from those seen following parenteral vaccination.Keywords
This publication has 0 references indexed in Scilit: