The Regulatory Role of MRP8 (S100A8) and MRP14 (S100A9) in the Transendothelial Migration of Human Leukocytes
- 1 January 1999
- journal article
- review article
- Published by S. Karger AG in Pathobiology
- Vol. 67 (5-6) , 230-232
- https://doi.org/10.1159/000028098
Abstract
The hallmark of developing inflammatory lesions is the excess migration of recruited phagocytes together with the enhanced cell surface expression of adhesion molecules. Recent investigations give evidence that the two myeloid-related proteins MRP8 (S100A8) and MRP14 (S100A9), which are abundant in activated or recruited phagocytes, may have a modulatory role in inflammatory responses. S100A9 displays a regulatory role in the transendothelial migration of human monocytes, and the secreted S100A8/A9 complex may serve as a transport protein to move arachidonic acid to its target cells.Keywords
This publication has 4 references indexed in Scilit:
- The Two Calcium-binding Proteins, S100A8 and S100A9, Are Involved in the Metabolism of Arachidonic acid in Human NeutrophilsJournal of Biological Chemistry, 1999
- Myeloid-related Protein (MRP) 8 and MRP14, Calcium-binding Proteins of the S100 Family, Are Secreted by Activated Monocytes via a Novel, Tubulin-dependent PathwayJournal of Biological Chemistry, 1997
- Cyclooxygenases-1 and −2 of Endothelial Cells Utilize Exogenous or Endogenous Arachidonic Acid for Transcellular Production of ThromboxaneJournal of Biological Chemistry, 1996
- The S100 protein familyTrends in Biochemical Sciences, 1988