Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia
Open Access
- 1 May 2006
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 107 (9) , 3724-3726
- https://doi.org/10.1182/blood-2005-08-3453
Abstract
FLT3 internal tandem duplications (FLT3/ITDs) in the juxtamembrane domain are found in approximately 25% of acute myeloid leukemia (AML) patients, ranging in siKeywords
This publication has 25 references indexed in Scilit:
- Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomesBlood, 2004
- Pediatric AML primary samples with FLT3/ITD mutations are preferentially killed by FLT3 inhibitionBlood, 2004
- The Structural Basis for Autoinhibition of FLT3 by the Juxtamembrane DomainMolecular Cell, 2004
- Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemiaBlood, 2003
- FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistanceBlood, 2003
- Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group UlmBlood, 2002
- Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: a Southwest Oncology Group studyBlood, 2002
- A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemiaBlood, 2002
- Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignanciesBlood, 2001
- Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cellsBritish Journal of Haematology, 2000