Ionized and Total Serum Calcium and Parathyroid Hormone in Hyperthyroidism

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Abstract
Total Ca and Ca2+ concentrations as well as parathyroid hormone [PTH] levels were measured in a group of hyperthryoid persons. Ca2+ and total Ca levels were elevated in 21 of 45 (47%) and in 12 of 45 (27%) thyrotoxic patients, respectively. Mean Ca2+ and total Ca levels were higher in these 45 patients than in normal persons. Using 2 radioimmunoassay systems for a total of 44 determinations, mean PTH levels were lower in thyrotoxic patients than in subjects with proved hyperparathyroidism. These data suggest that elevations of Ca2+ and total Ca concentrations occur frequently in thyrotoxic patients; Ca2+ concentrations may be elevated in a higher percentage of hyperthyroid subjects than are total Ca concentrations; and the hypercalcemia associated with thyrotoxicosis is not associated with elevated PTH levels.

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