Effects of long-term cimetidine on serum gastrin in duodenal ulcer

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Abstract
Basal and food-stimulated gastrin were measured in 16 patients with duodenal ulcer before and during long-term maintenance therapy with 400 mg cimetidine twice daily. Basal gastrin (mean±se) rose significantly from 27.5±3.1 pmol/liter precimetidine to 32.8±2.1, 37.2±2.6, and 38.5±3.3 pmol/liter at 1,3, and 6 months, respectively. The total integrated gastrin response to a protein meal was 1.67±0.18 nmol/liter/120 min pre-, and 2.54±0.35, 3.29±0.3, and 4.36±0.4 nmol/liter/120 min at 1, 3, and 6 months, respectively. These increases were significantly higher at each time period. This study has thus demonstrated a progressive increase in both basal and food-stimulated gastrin during cimetidine therapy, and this increase could theoretically lead to an increase in gastric acid secretion following cessation of cimetidine.