Anti-Candida Factors in Serum and Their Inhibitors. II. Identification of a Candida-Clumping Factor and the Influence of the Immune Response on the Morphology of Candida and on Anti-Candida Activity of Serum in Rabbits

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Abstract
The ability of normal rabbit serum to reduce populations of Candida albicans in vitro is due in part to the clumping of viable blastospores by a macroeuglobulin of fast beta mobility. Gradual loss of this clumping activity occurs during active immunization of rabbits with Candida, and this loss is clearly related to the appearance of humoral antibody to Candida rather than to a reduction in clumping factor. The antibody may interfere with clumping by competing successfully for binding sites on the blastospores and by being present in quantities sufficient to produce antibody excess. The 7S antibody to Candida also appears to promote mycelial transformation, possibly by mitigation of the activity of mitochondrial disulfide reductase or by induction of enzymes.

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