Back to square one: what do we know about the functions of Muscle LIM Protein in the heart?
- 30 December 2008
- journal article
- review article
- Published by Springer Nature in Journal of Muscle Research and Cell Motility
- Vol. 29 (6-8) , 155-158
- https://doi.org/10.1007/s10974-008-9159-4
Abstract
Muscle LIM Protein (MLP) is small, just 198 amino acid long protein, which is specifically expressed in slow skeletal muscle and cardiac tissues. This article will focus on the cardiac functions of MLP: the current knowledge about localisation data, binding partners and animal models for the protein will be summarised, and the role of MLP in maintaining a healthy heart be discussed. This review will furthermore attempt to identify gaps in our knowledge—and hence future research potential—with a special focus on MLP’s role in cardiac mechano-signalling.Keywords
This publication has 19 references indexed in Scilit:
- Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin–ECM adhesion complexDevelopmental Biology, 2008
- Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathyHuman Molecular Genetics, 2008
- HDAC4 and PCAF Bind to Cardiac Sarcomeres and Play a Role in Regulating Myofilament Contractile ActivityJournal of Biological Chemistry, 2008
- PICOT Attenuates Cardiac Hypertrophy by Disrupting Calcineurin–NFAT SignalingCirculation Research, 2008
- Paxillin and Ponsin Interact in Nascent Costameres of Muscle CellsJournal of Molecular Biology, 2007
- Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM proteinAmerican Journal of Physiology-Heart and Circulatory Physiology, 2007
- Genotype–phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethoninMolecular Genetics and Metabolism, 2005
- Decreased interactions of mutant muscle LIM protein (MLP) with N-RAP and α-actinin and their implication for hypertrophic cardiomyopathyCell and tissue research, 2004
- Alterations at the Intercalated Disk Associated with the Absence of Muscle Lim ProteinThe Journal of cell biology, 2001
- Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiationCell, 1994