Human developing enamel proteins exhibit a sex-linked dimorphism

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Abstract
Summary The amelogenin protein of developing dental enamel is generally accepted to mediate the regulation of the form and size of the hydroxyapatite crystallites during enamel biomineralization (1). A genetic disorder of enamel development (amelogenesis imperfecta) has been linked to theamelogenin geneAMEL (2–3), and loci regulating enamel thickness and tooth size have been mapped to the human sex chromosomes (4). In the human genome there are twoAMEL loci with one copy of the gene on each of the sex chromosomes (AMELX andAMELY), whereas in the mouse only anAMELX locus is present (5). It is presently unknown if humanAMELY is transcriptionally active. These observations prompted us to examine specimens of human developing enamel for sexual dimorphism at the protein level. We report here, for the first time, a diagnosis of differences in human enamel proteins which permits the distinction of specimens according to the sex of the individual.