The Sensitive Period and Malformation Syndrome Produced by Thalidomide in the Crab-Eating Monkey (Macaca fascicularis)
- 1 January 1973
- journal article
- research article
- Published by S. Karger AG in Journal of Medical Primatology
- Vol. 2 (5) , 267-276
- https://doi.org/10.1159/000460334
Abstract
The day of mating was designated as day zero of pregnancy. The pregnant animals received 5, 10, or 30 mg/kg of thalidomide orally, either as single doses on days 24, 25, 26, 27, 28, 29, or 51, or as multiple doses on days 25-27 of pregnancy. No malformations were observed following treatment on days 24, 29, and 51 of pregnancy. Malformations of the forelimbs were observed on days 25,26, and 27, and both fore- and hindlimb malformations were observed following treatment on day 28. The malformations were characterized by total absence (amelia) or partial absence (meromelia) of the free limb.Keywords
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