Cranial magnetic resonance imaging in genetically proven myotonic dystrophy type 1 and 2
- 1 June 2004
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Neurologie
- Vol. 251 (6) , 710-714
- https://doi.org/10.1007/s00415-004-0408-1
Abstract
Cranial magnetic resonance imaging (MRI) in 19 German patients with genetically proven myotonic dystrophy Type 1 (DM1, n = 10) or Type 2 (DM2, n = 9) showed pathological findings consisting of white matter lesions (WML) and/or brain atrophy in 9/10 DM1 and 8/9 DM2 patients. Anterior temporal WML (ATWML) were exclusively seen in DM1 patients. Our findings indicate a high frequency of central nervous system (CNS) involvement in both disorders. However, temporopolar pathology, previously associated with intellectual dysfunction, seems to be restricted to DM1.Keywords
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