Synthesis and Demonstration of Antiserotonin Activity of 1-Benzyl-2-methyl-5-hydroxytryptamine (BAS-phenol)
- 1 November 1957
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 96 (2) , 439-442
- https://doi.org/10.3181/00379727-96-23502
Abstract
A method was described for synthesis of l-benzyl-2-methyl-5-hydroxytryptamine involving cleavage of the methyl ether of l-benzyl-2-methyl-5-methoxytryptamine (BAS) by heating with pyridine hydrochloride. The phenol so produced exhibited powerful antiserotonin action either orally or intravenously in dogs. In the intravenous test it was the most potent antiserotonin thus far encountered. It also had considerable serotonin-like activity.Keywords
This publication has 6 references indexed in Scilit:
- A METHOD FOR INCREASING BRAIN SEROTONIN WITHOUT INCURRING SOME OF THE PERIPHERAL EFFECTS OF THE HORMONEProceedings of the National Academy of Sciences, 1957
- Benzyldimethylbufotenin, a Powerful Antimetabolite of SerotoninExperimental Biology and Medicine, 1956
- Serotonin, Antiserotonins and HypertensionNew England Journal of Medicine, 1956
- METHYLSEROTONINS AS POTENT ANTIMETABOLITES OF SEROTONIN ACTIVE BOTH INVITRO AND INVIVO1956
- The Synthesis of Tryptamines Related to SerotoninJournal of the American Chemical Society, 1955
- AN ANTISEROTONIN WHICH IS ACTIVE WHEN FED1953