INHIBITION OF ALGAE BY NYSTATIN

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Abstract
The polyenic antibiotic nystatin inhibited the growth of a broad range of algae at concentrations of 1 to 30 ug per ml. Organisms included in the Chlorophyta, Euglenophyta, Chryso-phyta, and Cyanophyta were inhibited, but a Bacillariophyceae was insensitive. Nystatin was lethal at concentrations which completely prevented growth. The polyene was absorbed by sensitive algae from aqueous medium. Nystatin produced K+ leakage, but did not inhibit dark respiration or photosynthetic oxygen production. The effects of the antibiotic on algae appear to be similar in many ways to those on yeast.