Colchicine and Testicular Function in Man
- 17 June 1976
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 294 (25) , 1384-1385
- https://doi.org/10.1056/nejm197606172942508
Abstract
COLCHICINE, used for centuries in the therapy of gout,1 has recently been shown to be beneficial in the prevention of attacks of familial Mediterranean fever.2 , 3 Reports of a toxic effect of colchicine in sperm production in man4 and laboratory animals5 have appeared and have led to recommendations for caution in its use in males in the reproductive age group. Although gout is predominantly a disease of males, no systematic study of the effect of colchicine on testicular function in man has been reported; such a study is described in the present paper.Study ProtocolSeven normal men, 20 to 25 . . .This publication has 8 references indexed in Scilit:
- Two Pools of Luteinizing Hormone in the Human Pituitary: Evidence from Constant Administration of Luteinizing Hormone-Releasing HormoneJournal of Clinical Endocrinology & Metabolism, 1974
- Colchicine Therapy for Familial Mediterranean FeverNew England Journal of Medicine, 1974
- A Controlled Trial of Colchicine in Preventing Attacks of Familial Mediterranean FeverNew England Journal of Medicine, 1974
- The Effect of Short-Term Testosterone Administration on Serum FSH, LH and Testosterone Levels: Evidence for Selective Abnormality in LH Control in Patients with Klinefelter's SyndromeJournal of Clinical Endocrinology & Metabolism, 1973
- Hypogonadotropic Eunuchoidism. II. Gonadal Responsiveness to Exogenous GonadotropinsJournal of Clinical Endocrinology & Metabolism, 1973
- Azoospermia Caused by Colchicine—A Case ReportFertility and Sterility, 1972
- Efficacy of Coulter Counter in Determining Low Sperm ConcentrationsAmerican Journal of Clinical Pathology, 1967
- Efficacy of Colchicine Prophylaxis in GoutAnnals of Internal Medicine, 1961