Colchicine and Testicular Function in Man

Abstract
COLCHICINE, used for centuries in the therapy of gout,1 has recently been shown to be beneficial in the prevention of attacks of familial Mediterranean fever.2 , 3 Reports of a toxic effect of colchicine in sperm production in man4 and laboratory animals5 have appeared and have led to recommendations for caution in its use in males in the reproductive age group. Although gout is predominantly a disease of males, no systematic study of the effect of colchicine on testicular function in man has been reported; such a study is described in the present paper.Study ProtocolSeven normal men, 20 to 25 . . .