Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting α-adrenergic activity. Synthesis and α1- and α2-adrenergic activity of 3-phenyl-3-piperidinols and their desoxy analogs
- 1 January 1995
- journal article
- Published by Elsevier in European Journal of Medicinal Chemistry
- Vol. 30 (11) , 869-880
- https://doi.org/10.1016/0223-5234(96)88306-1
Abstract
No abstract availableKeywords
This publication has 33 references indexed in Scilit:
- Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis and adrenergic activity of tetrahydrobenzocycloheptene derivativesEuropean Journal of Medicinal Chemistry, 1994
- Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of .alpha.- and .beta.-adrenergic receptorsJournal of Medicinal Chemistry, 1992
- Conformationally defined adrenergic agents. 1. Design and synthesis of novel .alpha.2-selective adrenergic agents: electrostatic repulsion based conformational prototypesJournal of Medicinal Chemistry, 1985
- New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent .beta.-adrenergic blocking propertiesJournal of Medicinal Chemistry, 1985
- α2-Adrenoceptor agonist properties of exo- and endo-isomers of 2-amino-6,7,dihydroxybenzo-norbornene designed as rigid catecholaminesJournal of Pharmacy and Pharmacology, 1983
- .alpha.-Adrenergic agents. 2. Synthesis and .alpha.1-agonist activity of 2-aminotetralinsJournal of Medicinal Chemistry, 1982
- .alpha.-Adrenergic agents. 1. Direct-acting .alpha.1 agonists related to methoxamineJournal of Medicinal Chemistry, 1981
- Molecular orbital studies on the mechanism of drug-receptor interaction. 1. Adrenergic drugs. Conformation and reactivity of isoproterenol and 1-(p-nitrophenyl)-2-isopropylaminoethanolJournal of Medicinal Chemistry, 1974
- THE STRUCTURE‐ACTIVITY RELATIONSHIPS OF BETA ADRENERGIC DRUGS AND BETA ADRENERGIC BLOCKING DRUGSAnnals of the New York Academy of Sciences, 1967
- Studies on the relationship between chemical constitution and physiological actionBiochemical Journal, 1933