Neurologic manifestations of celiac disease

Publisher Website
Google Scholar
Abstract
The strong HLA DQ2 or DQ8 haplotype association in celiac disease implicates a CD4+ T-cell–mediated process because HLA DQ molecules present processed peptide antigens to CD4+ T cells. CD4+ T cells extracted from celiac disease-affected intestine respond to transglutaminase modified gluten peptides presented by HLA DQ2 or DQ8. Patients’ peripheral blood T cells do not display such restriction. T cells in the gut are typically Th1 in phenotype, secreting large amounts of IFNγ. Both HLA-restricted CD4+ T cells with αβ T cell receptors and T cells bearing γδ T cell receptors (presumably not HLA DQ–restricted) infiltrate the small intestine.2