Resolution and synthesis of the individual enantiomers of the glycine antagonist 3-amino-1-hydroxypyrrolidin-2-one (HA-966)
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 1740-1742
- https://doi.org/10.1039/c39890001740
Abstract
The individual enantiomers of the glycine antagonist HA-966 (1) have been obtained by resolution via the bis-Boc-L-Phe (Boc = t-butoxycarbonyl) derivatives (2a and 2b) and by synthesis from D- and L-methionine.Keywords
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