Metabolism and macromolecular binding of dibenz(a,c)anthracene and dibenz(a,h)anthracene by mouse embryo cells in culture

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Abstract
The metabolism and consequent macromolecular binding of dibenz(a,c)anthracene and dibenz(a,h) anthracene by mouse embryo cells in culture was compared at approximately equal, low doses of hydrocarbon in the medium. Both hydrocarbons were metabolized more slowly than other hydrocarbons tested previously. The binding index (the extent of reaction of the hydrocarbon with the particular macromolecule resulting from metabolism of 1 mμMmole of hydrocarbon per ml of medium to which the cells were exposed) to DNA and RNA was low for the non‐carcinogenic dibenz(a,c)anthracene and at least 10 times higher for the carcinogenic dibenz(a,h) anthracene.