Recovery of Reoviruses from Wild and Laboratory Mice

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Abstract
Using virus isolation and serologic survey procedures, the occurrence of natural reovirus infection in mice has been detected. Four isolates of reovirus type 2 were recovered from urban and rural wild mice; 7 strains of reovirus type 3 were isolated from normal laboratory mice and transplant-induced mouse leukemias. Antibody to type 2 was found focally distributed in wild mice, but was not encountered in laboratory mice. A low titer serum inhibitor of type 3 HA and infectivity, possibly representing specific antibody, was prevalent in laboratory mice.