In vitro Antagonism of the Mediators of Allergy by a Benzopyrano-Benzopyran Carboxylic Acid PR-D-92-EA

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Abstract
PR-D-92-EA was tested on isolated guinea pig ileum and rat stomach strips for activity against mediators probably released after allergen antibody union. It antagonized the response produced by histamine, bradykinin, serotonin, prostaglandin E2, prostaglandin F2αand slow-reacting substance of anaphylaxis (SRS-A). The concentrations which blocked 50% of the response were 150, 145, 92, 70, 47, and 32 μg/ml, respectively. This compound may be useful in the treatment of allergic conditions.

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