Synthesis of and allergic contact dermatitis to bicyclo-[2,2,1]-heptyl-α-methylene-γ-butyrolactones derived from norbornene and camphene

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Abstract
Three new lactones, 2-oxo-3-methylene-4,7-methanobenzofuran and two .alpha.-methylene spirolactones, 3'',3''-dimethylspiro(2-oxo-3-methylenefuran-5,2''-norbornane), were synthesized and their skin activity was tested on 1 human volunteer and on guinea pigs. The man, sensitized to Frullania, was found sensitive to the above lactones and also reacted to frullanolide and alantolactone. The guinea pigs, experimentally sensitized to alantolactone, cross-reacted to 2-oxo-3-methylene-4,7-methanobenzofuran and the 2 .alpha.-methylene spirolactones, and also to isolantolactone and frullanolide.

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