DNA Polymerases in Parasitic Protozoans Differ from Host Enzymes
- 2 May 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 208 (4443) , 510-511
- https://doi.org/10.1126/science.7367875
Abstract
Analysis of extracts of the bloodstream forms of Trypanosoma brucei showed that both DNA polymerase-alpha and DNA polymerase-beta activities were present. The detection of DNA polymerase-beta in T. brucei demonstrates the presence of this enzyme in unicellular organisms. DNA polymerase-beta is present also in Leishmania mexicana. The DNA polymerases in T. brucei are immunologically distinct from the host enzymes. The structural differences between the parasite and the host enzymes could be exploited for the development of agents to combat parasitic diseases.Keywords
This publication has 9 references indexed in Scilit:
- Comparative Biochemistry and Drug Design for Infectious DiseaseScience, 1979
- Detection and characterization of DNA polymerase from Trypanosoma bruceiBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1979
- DNA polymerase of Dictyostelium discoideumBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976
- Phylogeny of DNA Polymerase-βScience, 1976
- Nomenclature of Eukaryotic DNA PolymerasesScience, 1975
- DNA polymerases of Euglena gracilis: heterogeneity of molecular weight and subunit structureNucleic Acids Research, 1975
- Deoxyribonucleic Acid Polymerase from Tetrahymena pyriformisPublished by Elsevier ,1974
- Antigenic Relationships in Mammalian DNA PolymeraseScience, 1972
- Isolation of salivarian trypanosomes from man and other mammals using DEAE-celluloseExperimental Parasitology, 1970