The design of inhibitors of protein kinase C; the solution conformation of staurosporine
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 3,p. 182-184
- https://doi.org/10.1039/c39910000182
Abstract
NMR spectra in several solvents show that the conformation of the tetrahydropyran ring in Staurosporine changes from a chair form in the free base to a boat conformation on protonation, mainly owing to the increased solvation requirement of –NH2Me+vs.–NHMe; implications for the bioactive conformation are discussed.Keywords
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