The Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen
- 1 December 2001
- journal article
- review article
- Published by Mary Ann Liebert Inc in Viral Immunology
- Vol. 14 (4) , 311-317
- https://doi.org/10.1089/08828240152716565
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), is associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (6,7,10). While the vast majority of tumor cells from these malignancies are latently infected, only a small subset of viral genes are actually expressed (5,40,47). Of these genes, the latency-associated nuclear antigen (LANA-1, LNA, or LNA1) is the only protein consistently shown to be highly expressed by in situ hybridization and immunohistochemistry (11,20,21,32). Moreover, within the past few years LANA-1 has proven to be a quite versatile protein, playing not only a pivotal role in KSHV episome persistence, but also in interacting with and influencing several cellular genes.Keywords
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