GAMMA GLOBULIN IN EPIDEMIC HEPATITIS
- 7 August 1954
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 155 (15) , 1302-1305
- https://doi.org/10.1001/jama.1954.03690330006002
Abstract
The hypothesis1that the use of 0.01 to 0.06 ml. of gamma globulin per pound (0.5 kg.) of body weight during epidemics of viral hepatitis produces a passive-active immunity when the persons so treated continue at risk is based on the presence or absence of icterus in control and gamma globulin-treated groups. The results have been statistically significant in studies both in the field2and in closed institutions1in which epidemics existed. In this study the possibility was explored that, if gamma globulin were administered at a dosage level close to its lower limit of effectiveness, the more careful detection of subsequent anicteric cases of hepatitis might indicate whether mild or attenuated infections occurred and superimposed an active immunity on the protection afforded by the globulin. This report presents the incidence of abnormal findings in liver function tests in both control and gamma-globulin-treated groups during an epidemicKeywords
This publication has 1 reference indexed in Scilit:
- INFECTIOUS HEPATITISJAMA, 1951