Thioredoxin reductase as a pathophysiological factor and drug target
Open Access
- 1 October 2000
- journal article
- review article
- Published by Wiley in European Journal of Biochemistry
- Vol. 267 (20) , 6118-6125
- https://doi.org/10.1046/j.1432-1327.2000.01703.x
Abstract
Human cytosolic thioredoxin reductase (TrxR), a homodimeric protein containing 1 selenocysteine and 1 FAD per subunit of 55 kDa, catalyses the NADPH‐dependent reduction of thioredoxin disulfide and o...Keywords
This publication has 54 references indexed in Scilit:
- Expression of the thioredoxin-thioredoxin reductase system in the inflamed joints of patients with rheumatoid arthritisArthritis & Rheumatism, 1999
- High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA , selB and selC genes 1 1Edited by M. GottesmanJournal of Molecular Biology, 1999
- Autoantibody to Thioredoxin Reductase in an Ovarian Cancer PatientBiochemical and Biophysical Research Communications, 1998
- Efficient Reduction of Lipoamide and Lipoic Acid by Mammalian Thioredoxin ReductaseBiochemical and Biophysical Research Communications, 1996
- NK-lysin, a Disulfide-containing Effector Peptide of T-lymphocytes, Is Reduced and Inactivated by Human Thioredoxin ReductaseJournal of Biological Chemistry, 1996
- Deoxyribonucleoside Triphosphate Pools and Growth of Glutathione-Depleted 3T6 Mouse FibroblastsBiochemical and Biophysical Research Communications, 1996
- A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeastMolecular Genetics and Genomics, 1996
- Cloning and sequencing of a human thioredoxin reductaseFEBS Letters, 1995
- Purification and Functional Analysis of the Mycobacterium leprae Thioredoxin/Thioredoxin Reductase Hybrid ProteinPublished by Elsevier ,1995
- EF-hands calcium binding regulates the thioredoxin reductase/thioredoxin electron transfer in human keratinocytesBiochemical and Biophysical Research Communications, 1989