PARANEOPLASTIC PEMPHIGOID‐PEMPHIGUS? SUBEPIDERMAL BULLOUS DISEASE WITH PEMPHIGUS‐LIKE DIRECT IMMUNOFLUORESCENCE
- 1 January 1993
- journal article
- Published by Wiley in International Journal of Dermatology
- Vol. 32 (1) , 48-51
- https://doi.org/10.1111/j.1365-4362.1993.tb00964.x
Abstract
Background. Paraneoplastic pemphigus is a recently described variant of pemphigus, in which classic immunologic features of pemphigus are associated with subepidermal erythema multiforme-like bullae. Case Reports. Two patients with underlying malignant neoplasm had a bullous disease, which had clinical and histologic features suggestive of bullous pemphigoid while direct immunofluorescence revealed intercellular deposits of IgG and C3 throughout the malpighian layer of epidermis, a pattern usually diagnostic for pemphigus. Indirect immunofluorescence studies were negative. One mg/kg/day prednisone was enough to cure the eruption in a couple of weeks without any recurrence. Conclusions. The disease differs from the recently reported paraneoplastic pemphigus and from other bullous diseases associating circulating pemphigus-like antibodies with clinical, histologic, and often even immunologic features of bullous pemphigoid.Keywords
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