Analysis of Heterogeneity of Atypia Within Melanocytic Nevi

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Abstract
DUE TO increasing numbers of biopsy specimens of partially shaved nevi received in our dermatopathology laboratory, we thought that it would be interesting and important to determine the incidence of histologic heterogeneity within atypical nevi. It is generally appreciated that nevi may exhibit clinical and histologic atypia.1-3 For this study, sections of 298 histologically atypical nevi were reviewed to evaluate the heterogeneity of atypia within individual nevi in a more precise fashion. Heterogeneity of atypia is important because biopsy specimens of partially removed nevomelanocytic neoplasms may not be representative of the entire lesion.