Inhibition of mouse epidermal 12-lipoxygenase by 2,3,4-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-l,4-benzoquinone (AA861)
- 1 January 1985
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 37 (1) , 71-73
- https://doi.org/10.1111/j.2042-7158.1985.tb04938.x
Abstract
2,3,5‐Trimethyl‐6‐(12‐hydroxy‐5, 10‐dodecadiynyl)‐1.4‐benzoquinone (AA861) strongly inhibited epidermal lipoxygenase activity which was determined by the formation of [14 C]12‐hydroxy‐5,8,10,14‐eicosatetraenoic acid by incubating [l4 C]arachidonic acid with cytosol fraction of epidermal homogenate of ***CD‐1 mice. AA861 failed to inhibit epidermal cyclooxygenase activity. The present results indicate that AA861 is a potent inhibitor of 12‐lipoxygenase in mouse epidermis (IC50 1.9 μM).Keywords
This publication has 17 references indexed in Scilit:
- Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibitionCarcinogenesis: Integrative Cancer Research, 1983
- Aortic smooth muscle cell migration caused by platelet-derived growth factor is mediated by lipoxygenase product(s) of arachidonic acidBiochemical and Biophysical Research Communications, 1983
- Selective inhibition of 5‐lipoxygenase by 5,6‐methanoleukotriene A4, a stable analogue of leukotriene A4FEBS Letters, 1982
- Nafazatrom (bay g 6575) inhibition of tumor cell lipoxygenase activity and cellular proliferationFEBS Letters, 1982
- Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathwayCarcinogenesis: Integrative Cancer Research, 1982
- Arachidonic Acid Transformations in Normal and Psoriatic SkinJournal of Investigative Dermatology, 1979
- A new approach to anti-inflammatory drugsBiochemical Pharmacology, 1979
- 1-phenyl-3-pyrazolidone: An inhibitor of cyclo-oxygenase and lipoxygenase pathways in lung and plateletsProstaglandins, 1978
- On the formation of thromboxane B2 and 12L-hydroxy-5, 8,10,14-eicosatetraenoic acid (12 ho-20:4) in tissues from the guinea pigBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1976
- Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human PlateletsProceedings of the National Academy of Sciences, 1974