JOLIPEPTIN, A NEW PEPTIDE ANTIBIOTIC
- 1 January 1972
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 25 (5) , 309-314
- https://doi.org/10.7164/antibiotics.25.309
Abstract
Jolipeptin causes a release of 260 mμ, absorbing materials from the jolipeptin-sensitive strains, Escherichia coli B and Bacillus subtilis PCI 219. Moreover, Jolipeptin lyses not only protoplasts of B. subtilis PCI 219 and Micrococcus lysodeikticus, but also spheroplasts of E. coli B and Pseudomonas aeruginosa IFO 3901. In contrast, colistin, produced simultaneously with Jolipeptin, lysed spheroplasts of E. coli B and P. aeruginosa IFO 3901, but not protoplasts of gram-positive bacteria, the latter being colistin-insensitive strains. On the basis of this study, it was concluded that Jolipeptin acts primarily on the cellular membrane.Keywords
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