Comparative Study of Glycolipid Compositions of Plasma Membranes among Two Types of Rat Ascites Hepatoma and Normal Rat Liver
- 1 May 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 83 (5) , 1517-1520
- https://doi.org/10.1093/oxfordjournals.jbchem.a132062
Abstract
Glycolipid compositions of purified plasma membranes from rat ascites hepatomas, two island-forming cell-lines and two cell-lines of the free-type, and normal rat liver were compared. Ceramide monohexoside (CMH), ceramide dihexoside (CDH), and hematoside (GM3), were found in normal rat liver cell membranes. The island-type hepatomas contained ceramide trihexoside (CTH) and globoside besides CMH, CDH, and GM3. The free-type of hepatomas were characterized by the presence of asialo-type gangliosides but not GM3. Blood group H active fucolipid was a major glycolipid in the free-type of ascites hepatoma cell (AH 7974 F). The increase of glycolipid content in cell membranes seemed to be accompanied with a decrease of cell adhesiveness.This publication has 0 references indexed in Scilit: