Remarkable elevation of leukotriene B4 in rat skin after induction of UV photodermatitis

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Abstract
Leukotriene B4 in the skin was remarkably elevated in the rat, but not in the guinea pig or the mouse 48 h after UV-B irradiation. These results were consistent with interspecies difference of PMN infiltration caused by UV-B irradiation. LTB4 in the rat skin was determined by both high-performance liquid chromatography and radioimmunoassay. LTB4 in the rat skin started to increase 24 h after irradiation and became about 65-fold higher in the irradiated site than in the nonirradiated site at the end of 48 h. This elevation was strongly inhibited by topical application of two 5-lipoxygenase inhibitors, AA-861 and piriprost, although the inflammatory reaction or infiltration of polymorphonuclear leukocytes was not much improved.