Interleukin‐1 Alpha mRNA Induced by Cycloheximide, PMA, and Retinoic Acid Is Reduced by Dexamethasone in PAM‐212 Keratinocytes
- 17 December 1988
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 548 (1) , 283-290
- https://doi.org/10.1111/j.1749-6632.1988.tb18816.x
Abstract
Keratinocytes in culture produce detectable amounts of IL-1 alpha mRNA constitutively and can be stimulated to express increased amounts of IL-1 alpha mRNA by cycloheximide, PMA, and retinoic acid. Dexamethasone decreases the amount of IL-1 mRNA induced by these agents, as well as constitutive IL-1 alpha mRNA. RU 486, which interferes with glucocorticosteroid-receptor binding, decreases inhibition of TPA stimulation of IL-1 alpha mRNA by dexamethasone, which suggests that the inhibition by dexamethasone is through a conventional ligand-receptor mechanism.Keywords
This publication has 29 references indexed in Scilit:
- Bacterial lipopolysaccharide (endotoxin) enhances expression and secretion of beta 2 interferon by human fibroblasts.The Journal of Experimental Medicine, 1987
- Dexamethasone inhibits feedback regulation of the mitogenic activity of tumor necrosis factor, interleukin‐1, and epidermal growth factor in human fibroblastsJournal of Cellular Physiology, 1987
- Interleukin 1 gene expression in cultured human keratinocytes is augmented by ultraviolet irradiation.Journal of Clinical Investigation, 1987
- Systemic administration of etretin increases epidermal interleukin I in the ratBritish Journal of Dermatology, 1987
- Keratinocyte Membrane-Associated Epidermal Cell-Derived Thymocyte-Activating Factor (ETAF)Journal of Investigative Dermatology, 1986
- Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.The Journal of Experimental Medicine, 1986
- Hydrocortisone Reduces Both Constitutive and UV-Elicited Release of Epidermal Thymocyte Activating Factor (ETAF) by Cultured KeratinocytesJournal of Investigative Dermatology, 1986
- Cloning and expression of murine interleukin-1 cDNA in Escherichia coliNature, 1984
- Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generationNature, 1979
- Studies on steroid fever II. Pyrogenic and anti-pyrogenic activity in vitro of some endogenous steroids of manJournal of Clinical Investigation, 1970