Spasmolytic agents. 2. 1,2,3,4-Tetrahydro-2-naphthylamine derivatives
- 1 November 1982
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 25 (11) , 1358-1363
- https://doi.org/10.1021/jm00353a016
Abstract
N-[(Benzoyloxy)alkyl]-1,2,3,4-tetrahydro-2-naphthylamine derivatives were synthesized from 1,2,3,4-tetrahydro-2-naphthylamines and evaluated for their spasmolytic activity. Some of these compounds showed a nerve-selective effect on colon rather than stomach in anesthetized dogs and were equal to or more active than the reference drug (mebeverine). The biological data have indicated some structure-activity relationships. Among these compounds, N-ethyl-N-[6-[(3,4-dimethoxybenzoyl)oxy]hexyl]-1,2,3,4-tetrahydro-6-methoxy-2-napththylamine hydrochloride (63) was the most active spasmolytic agent.This publication has 1 reference indexed in Scilit:
- Reserpine Analogs; Phenethylamine Derivatives1Journal of Medicinal Chemistry, 1963