Cytogenetic Adaptive Response of Cultured Fish Cells to Low Doses of X-rays.
Open Access
- 1 January 1992
- journal article
- Published by Oxford University Press (OUP) in Journal of Radiation Research
- Vol. 33 (4) , 267-274
- https://doi.org/10.1269/jrr.33.267
Abstract
The adaptive response was examining chromosomal aberrations and micronucleus in cultured fish cells, ULF-23 (mudminnow) and CAF-31 (gold fish). When cultured fish cells were first irradiated with small doses of X-rays, they became less sensitive to subsequent exposures to high doses. The effective adaptive dose was 4.8 cGy- 9.5 cGy. Adaptive doses given cells in the G1 phase were more effective than when given in the S phase. The adaptive response was maximal at 5 hours and disappeared at 10 hours after the adaptive dose. The expression of the response was inhibited by treatment with 3-aminobenzamide, as reported for mammalian cells, and with arabinofuranoside cytosine, an inhibitor of DNA polymerase alpha. Caffeine, an inhibitor of post-replicational repair, had no effect on the response.Keywords
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