Bicyclic heterocycles with nitrogen at the ring junction. Part 2. Application of the Dakin–West reaction to the synthesis of imidazo[5,1-f]-1,2,4-triazin-4(3H)-ones
- 1 January 1980
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 1139-1146
- https://doi.org/10.1039/p19800001139
Abstract
A series of novel acylamino α-keto-esters (4) have been prepared via a Dakin–West reaction of acylated a-aminoacids and ethyl oxalyl chloride. Their use in a general synthesis of imidazo[5,1-f]-1,2,4-triazin-4(3H)-ones (7) is described. The conversion of the imidazotriazinones into the corresponding imidazo[5,1-f]-1,2,4-triazines (20) and their 3,4-dihydro-derivatives (19) are also reported.Keywords
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