FISH and PRINS, a strategy for rapid chromosome screening: application to the assessment of aneuploidy in human sperm
- 1 January 1996
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 72 (1) , 34-36
- https://doi.org/10.1159/000134155
Abstract
The co-utilization of FISH and PRINS techniques for in situ chromosome screening was tested on human sperm nuclei. We used a centromeric repeat probe specific for chromosome 4 for FISH. PRINS reactions were performed with α-satellite primers specific for either chromosome 9 or chromosome 18. Double labeling was obtained and estimates of disomy rates were carried out for the three chromosomes.Keywords
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