COMPARISON OF THE CEREBRAL FUNCTION MONITOR AND PLASMA CONCENTRATIONS OF THIOPENTONE AND ALPHAXALONE DURING TOTAL I.V. ANAESTHESIA WITH REPEATED BOLUS DOSES OF THIOPENTONE AND ALTHESIN

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Abstract
Repeated bolus doses of thiopentone or Althesin were administered to 10 patients every 240 s while cerebral electrical activity was recorded with the Cerebral Function Monitor (CFM). Peripheral venous blood samples were collected at 60 and 225s after each bolus dose for the measurement of plasma concentrations of the drugs. Significant correlations in the range r = 0.56–0.96 (P = 0.02–0.00001) between plasma thiopentone or alphazalone concentrations and the upper and lower edges of the CFM trace were found. For the patiena with relatively poor correlations, better correlations were obtained when 60- and 22 5-s samples were analysed separately.

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