Factors Influencing Alveolar-Arterial Oxygen Pressure Gradient

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Abstract
The A-a oxygen pressure gradient was determined in anesthetized dogs. Data obtained when pulmonary ventilation and alveolar oxygen tension are varied independently suggests that: a) the magnitude of the A-a oxygen pressure gradient correlates directly with the Pa oo2. b) In the anesthetized dog venous admixture seems to be constant, unrelated to the changes in ventilation produced by positive-negative pressure breathing. c) Venous admixture is the most important factor in producing the A-a gradient in the dog.

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