Effect of probenecid on the excretion of ampicillin in human bile
Open Access
- 1 April 1973
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 47 (4) , 782-786
- https://doi.org/10.1111/j.1476-5381.1973.tb08205.x
Abstract
1 Ampicillin concentrations were determined in serum and bile after intravenous injection into patients with T-tube bile drainage of 1 gram ampicillin before and during probenecid medication. The concentrations were followed up to fifteen hours after injection. 2 Probenecid increased the half-life of ampicillin in serum from 74 minutes to 137 minutes. 3 Ampicillin concentrations in bile were higher following probenecid medication and a concentration over 5 μg/ml was obtained for 3 h longer than before probenecid. 4 The ampicillin concentrations in bile were approximately the same as those in serum both before and during probenecid medication suggesting passive transport of ampicillin from blood to bile. 5 A combined treatment of ampicillin and probenecid might be of clinical value in the therapy of cholangitis and typhoid carriers.Keywords
This publication has 7 references indexed in Scilit:
- Treatment of chronic typhoid carriers with ampicillin.1971
- Treatment of Chronic Typhoid Carriers With AmpicillinPublished by American Medical Association (AMA) ,1971
- Ampicillin Levels in Human Bile in the Presence of Biliary Tract DiseaseBMJ, 1969
- AMPICILLIN LEVELS IN HUMAN BILEBritish Journal of Pharmacology and Chemotherapy, 1965
- Treatment of Biliary Infections with AmpicillinPublished by Oxford University Press (OUP) ,1964
- AMPICILLIN ACTIVITY IN VITRO AND ABSORPTION AND EXCRETION IN NORMAL YOUNG MENThe Lancet Healthy Longevity, 1963