N‐Methyl‐d‐Aspartate Injection Into the Massa Intermedia Facilitates Development of Limbic Kindling in Rats
- 1 November 1992
- Vol. 33 (6) , 965-970
- https://doi.org/10.1111/j.1528-1157.1992.tb01745.x
Abstract
The effect on limbic kindling of N-methyl-D-aspartate (NMDA) injection into the midline thalamus of rats was investigated. Repeated injection of 25 nmol/0.5 microliters NMDA (experimental group) into the massa intermedia (MI), particularly into the reuniens nucleus, caused tonic and/or clonic generalized convulsion associated with temporal limbic EEG seizure discharge. This did not occur after injection of phosphate-buffered saline (PBS, control group). When the animals were subjected to subsequent kindling at either the hippocampus (HP) or the amygdala (AM), only the experimental group showed a significant facilitation of kindling rate. The results suggest that an NMDA receptor in the reuniens nucleus participates in modulation of temporal limbic excitability and seizure development.Keywords
This publication has 26 references indexed in Scilit:
- Midline Thalamus and Amygdaloid KindlingPublished by Springer Nature ,1990
- Midline thalamic lesion and feline amygdaloid kindling. II. Effect of lesion placement upon completion of primary site kindlingElectroencephalography and Clinical Neurophysiology, 1988
- Midline thalamic lesion and feline amygdaloid kindling. I. Effect of lesion placement prior to kindlingElectroencephalography and Clinical Neurophysiology, 1988
- Cortical and subcortical afferents to the amygdala of the rhesus monkey (Macaca mulatta)Brain Research, 1980
- Cells of origin of the hippocampal afferent projection from the nucleus reuniens thalamiCell and tissue research, 1979
- Corpus callosum and propagation of afterdischarge to contralateral cortex and thalamusNeurology, 1978
- The connections of the nucleus reuniens thalami: Evidence for a direct thalamo‐hippocampal pathway in the ratJournal of Comparative Neurology, 1978
- Interactions between thalamus and cortex in experimental epilepsy in the catExperimental Neurology, 1976
- A permanent change in brain function resulting from daily electrical stimulationExperimental Neurology, 1969
- Diffuse projection systems: The integrative action of the thalamic reticular systemElectroencephalography and Clinical Neurophysiology, 1949