An Improved Procedure for the Synthesis of 4-Oxopimelate-Derived Materials.1
- 1 March 1983
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 13 (3) , 243-254
- https://doi.org/10.1080/00397918308065996
Abstract
In the course of one of our synthetic projects we required efficient access to 4-ethylenedioxy-2-carbomethoxycyclohexanone 6.2,4,5 Synthesis of this material has been traditionally accomplished by conversion of 2-furaldehyde 1 to furylacrylic acid 2 via an Organic Synthesis procedure (90%),3 followed by treatment of 2 with methanolic HCI to afford dimethyl 4-oxopimelate 3 in reported yields of 60%4 and 80%.5 This latter step requires an especially arduous procedure involving removal of the highly corrosive HCl-saturated methanol by distillation; adding benzene, an additional solvent distillation; retreatment of the residue with methanolic sulfuric acid (apparently to reesterify some monoacid produced from the initial HCl treatment4), and ultimately a vacuum distillation.Keywords
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