INCREASED SUSCEPTIBILITY TO LETHAL EFFECTS OF BACTERIAL LIPOPOLYSACCHARIDE IN MICE WITH B-CELL LEUKEMIA

  • 1 January 1981
    • journal article
    • research article
    • Vol. 66  (4) , 745-753
Abstract
Susceptibility to the lethal effects of bacterial [Salmonella typhi] lipopolysaccharide (LPS) increased more than 100-fold in BALB/c mice given syngeneic B cell tumor [mouse leukemia BCL1 cells] transplants. The increased susceptibility to LPS that developed during the following weeks paralleled tumor growth in the liver and spleen. The tumor-bearing animals also developed an enhanced capacity to clear colloidal C from the blood, consistent with increased activity of the RES. Although hypersusceptibility to LPS had been reported in a number of animal models, this is the 1st demonstration in a tumor model that susceptibility correlates with tumor burden.

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