Pubertas praecox in craniopharyngioma

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Abstract
A case of craniopharyngioma associated with true precocious puberty is reported in a child operated on when she was 2 yr and 8 mo. of age. Precocity was noted 10 mo. after operation and was fully documented 1 yr later. A pneumoencephalogram showed a recurrence of tumor in the hypothalamic area. Hormonal therapy was instituted to stop sexual maturation. Reoperation was undertaken only when her visual symptoms reappeared. She received a postoperative course of radiotherapy. On last examination, she was neurologically well and computerized tomography did not show further growth of the residual tumor. The diagnosis of precocious puberty and its etiology in this patient are discussed.