Diphosphonates Inhibit Formation of Calcium Phosphate Crystals in vitro and Pathological Calcification in vivo
- 19 September 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 165 (3899) , 1264-1266
- https://doi.org/10.1126/science.165.3899.1264
Abstract
Two diphosphonates containing the P-C-P bond, CH 3 C(OH)(PO 3 HNa) 2 and H 2 C(PO 3 HNa) 2 , inhibit the crystallization of calcium phosphate in vitro and prevent aortic calcification of rats given large amounts of vitamin D 3 . The diphosphonates therefore have effects similar to those described for compounds containing the P-O-P bond but are active when administered orally.Keywords
This publication has 5 references indexed in Scilit:
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