Blood Volume and Plasma Protein Replacement Following Acute Blood Loss in Normal Man

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Abstract
Following prelabeling of the albumin space by iodinated I 131 serum albumin, six normal ambulatory male volunteers were phlebotomized 15% to 20% of blood volume to characterize their response to phlebotomy. Blood volume, as reflected by serial determinations of hematocrit values, was restored more slowly than predicted by previous studies. No significant postphlebotomy influx of salt and water was observed and the plasma protein concentration remained remarkably constant throughout the study. The plasma proteins replaced in response to phlebotomy were clearly from a preexisting extravascular pool and new protein formation contributed little to the restorative process. The findings reemphasize the fact that the hematocrit value is a relatively poor index of blood volume deficit following acute blood loss in normal man.

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