The Toxic Effects of Clofibrate and Its Metabolite on Mammalian Skeletal Muscle: An Electrophysiologigal Study

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Abstract
Membrane electrical parameters of rat extensor digitorum longus muscles were analysed in vitro, with intracellular microelectrodes, after chronic treatment with Clofibrate or after in vitro application of chloro-phenoxyisobutyric acid, the in vivo metabolite of Clofibrate. Clofibrate caused only a 38% decrease in the membrane chloride conductance while its metabolite induced a large decrease of chloride conductance and drastic changes in the excitability characteristics of the muscles sampled. The capability of Clofibrate to induce two types of myotonia is discussed.