Primary and Secondary Antibody Response in Rats to Bacterial and Sheep Erythrocyte Antigens

Open Access
Publisher Website
Google Scholar
Abstract
Summary: The response of rats to primary and secondary stimulation with bacterial and sheep erythrocyte antigens has been examined. Response to RBC and Str consists of a rapid rise and fall both after primary and secondary injection. The bacterial antigens elicit a rise of titer similar to that produced by RBC and Str. This titer, however, persists for a long period of time in a steady state fashion and second injection leads to a titer rise not very much higher than the steady state level. Cellular proliferation after first and second injection of all antigens shows a similar sequence of events differing only in degree of magnitude but showing essentially the same cell types.