INHIBITION OF LEUKOPOIESIS BY SERA FROM TRYPANOSOMA CONGOLENSE INFECTED CALVES - PARTIAL CHARACTERIZATION OF THE INHIBITORY FACTOR

  • 1 January 1980
    • journal article
    • research article
    • Vol. 31  (2) , 232-238
Abstract
Sera collected from calves infected with T. congolense inhibited bovine granulocytle/macrophage colony formation in vitro, but not erythroid colony formation. The inhibitor was TCA [trichloroacetate] precipitable in nature and on Sephadex G-200 chromatography, it was eluted with the 2nd major peak. Sonicated T. brucei, T. congolense and T. theileri added directly into the cultures had no effect on granulocyte-macrophage colony formation, but induced significant enhancement of erythroid colony formation.